The regulation of chromatin structure is essential for all eukaryotic organisms. Our research interests are to determine the contribution of chromatin to mechanisms that maintain genomic integrity and metabolic homeostasis in the context of disease and development.  We utilize a varied experimental approach that includes computational, biochemical, molecular and cellular assays in both yeast and mammalian systems to ascertain the contribution of chromatin remodelers and histone modifiers to carcinogen susceptibility and metabolic gene expression. We hope to contribute to the formulation of epigenetic therapies that treat genomic and metabolic dysfunction, which influence cancer, heart disease, and diabetes to name a few.